Duchenne muscular dystrophy (DMD) is a genetic condition marked by the gradual deterioration of muscle tissue. Recent studies have revealed that DMD arises from specific changes in a vital protein called dystrophin, responsible for maintaining the integrity of muscle cells. The gene responsible for producing this protein follows an inheritance pattern known as X-linked recessive.
Which of the following statements is wrong according to the above?
A) DMD is a sex-linked inherited disease.
B) Women are more likely to suffer from DMD than men.
C) The rate at which the mutated allele spreads is influenced by the rate at which the associated X chromosome spreads within the population.
D) To develop the condition, a man must inherit one of the recessive alleles of this gene.
E) To develop the condition, a woman must inherit two recessive alleles of this gene.
IMAT 2023 · Question 11
Q11 - Hereditary diseases
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The correct answer is B) Women are more likely to suffer from DMD than men.
X-linked recessive means men need one copy of the allele (they only have one X), while women need two. So the disease is much more common in men, and B is the false statement.
Everything else in the list is just a correct description of X-linked recessive inheritance.
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