IMAT 2023 · Question 17

Q17 - Inheritance patterns

Listed below are three different families with genotypes related to colour blindness which is an X-linked recessive disorder. Family 1: mother XᴿXʳ, father XᴿY Family 2: mother XʳXʳ, father XᴿY Family 3: mother XᴿXʳ, father XʳY Among the families, which ones can have a colour-blind daughter? A) 2 and 3 B) 1 and 2 C) 3 D) 1 E) 2
Pinned

The correct answer is C) 3.

A daughter always gets her father's X. For her to be colour-blind (XʳXʳ), the father must be XʳY and the mother must be able to pass on Xʳ.

Families 1 and 2 have an XᴿY father, so their daughters always get a normal X: at worst they're carriers. Only family 3 has an XʳY father, and the carrier mother gives a 50% chance of an XʳXʳ daughter.

Only family 3.

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