IMAT 2025 · Question 12

Q12 - The Krebs cycle

Each acetyl-CoA molecule that enters the Krebs cycle produces: A) 2 NADH, 2 FADH₂, 2 GTP and 2 molecules of CO₂ B) 3 NADH, 1 FADH₂, 2 GTP and 3 molecules of CO₂ C) 3 NADH, 1 FADH₂, 1 GTP and 3 molecules of CO₂ D) 1 NADH, 3 FADH₂, 1 GTP and 2 molecules of CO₂ E) 3 NADH, 1 FADH₂, 1 GTP and 2 molecules of CO₂
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The correct answer is E) 3 NADH, 1 FADH₂, 1 GTP and 2 molecules of CO₂.

One turn of the Krebs cycle (one acetyl-CoA) gives 3 NADH, 1 FADH₂, 1 GTP and 2 CO₂.

The options with 3 CO₂ are adding in the CO₂ from the link reaction (pyruvate → acetyl-CoA), which happens before the cycle. Also remember that one glucose gives two acetyl-CoA, so everything doubles per glucose.

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